The #1 GLP-3R Research Grade Peptide USA

TRIPLE
RECEPTORDOMINANCE

✓ Fat Burning & Energy Research

Triggers fat-burning pathways for enhanced metabolic activity.

✓ Appetite Control Research

Supports appetite-regulation signaling pathways for reduced intake.

✓ Blood Sugar & Insulin Research

Optimizes glucose control pathways and insulin response activity.

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PureOne Peptides
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GLP-3R10mg · ~99% Purity
Lab Tested in - USA
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1 Vial · 10mg GLP-3R RUO
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GLP
Triple-Receptor Peptide · Advanced Metabolic Model
GLP-1 Appetite Pathway
GIP Insulin Response
GCG Fat Metabolism
3×
Receptor Activation
~6 Days
Sustained Activity
About The Compound

What
GLP-3R Is

GLP-3R is an advanced triple-receptor research peptide engineered to simultaneously target GLP-1, GIP, and glucagon pathways — creating a uniquely comprehensive model for metabolic and energy regulation studies.

Unlike single or dual agonists, GLP-3R is designed to deliver multi-pathway activation, enabling researchers to explore appetite signaling, insulin response, and fat metabolism within a single compound.

Enhanced with a fatty-acid modification, GLP-3R demonstrates extended activity of up to 6 days — allowing for sustained receptor engagement and reduced dosing frequency in long-cycle research protocols.

3 Receptors Targeted
~6 Days Active Duration
1× Weekly Dosing Model
What We Offer

The Research
Benefits

Based on published study data, here are the areas shown with real breakthroughs.

Body Weight Research

GLP-3R has demonstrated significant outcomes in body weight studies, with research subjects showing up to 24% reduction over 48 weeks — one of the most notable findings in metabolic research to date.

24% Reduction48 WeeksPhase 2 Data
→
Glucose Control Studies

Designed to support blood sugar research, GLP-3R enhances insulin-related pathways by activating pancreatic response mechanisms, helping researchers explore improved glycemic regulation.

Insulin ActivityGlucose BalanceDiabetes Focus
→
Fat Metabolism Research

Beyond appetite pathways, GLP-3R uniquely activates the glucagon receptor — signaling fat cells to release and oxidize stored lipids, offering a deeper layer of metabolic study.

LipolysisEnergy BurnTriple Action
→
Cardiovascular Research

Ongoing investigations explore GLP-3R’s role in cardiovascular markers, including blood pressure, lipid profiles, and systemic inflammation — key factors in heart health studies.

Blood PressureCholesterolInflammation
→
Liver Fat Analysis

Emerging data suggests GLP-3R may significantly reduce liver fat levels, making it a valuable compound for studying metabolic liver conditions and fatty liver progression.

Liver FatMetabolic HealthNAFLD Research
→
Receptor Binding Studies

GLP-3R’s multi-receptor activity enables advanced pharmacological research, allowing scientists to study differential binding strength across GLP-1, GIP, and glucagon pathways.

Triple ReceptorBinding StudyPharmacology
→
GLP-3R Peptide
The World's First
Triple-Receptor Agonist
One molecule. Three metabolic pathways.
GLP-3R
💚
GLP-1 Receptor
⭐
GIP Receptor
🔥
Glucagon Receptor
10mg Vial
~99% Purity
Lab Tested
Triple Mechanism
01 · GLP-1 RECEPTOR
Hits the GLP-1 Receptor

The same receptor targeted by the most powerful weight-loss drugs on the market. Activation slows gastric emptying, reduces hunger signals at the brain level, and modulates glucose-dependent insulin secretion — all in one pathway.

✓ Appetite Suppression · Brain-Level Signaling
02 · GIP RECEPTOR
GIP Receptor — Fat Storage Control

GLP-3R activates the GIP receptor with nearly 9× the potency of the body's own natural signal. GIP directly controls how fat cells store lipids and how much insulin the pancreas produces — a lever no single-target peptide can pull.

✓ Fat Storage Modulation · Insulin Sensitivity
03 · GLUCAGON RECEPTOR
The Secret Metabolic Weapon

No other research peptide hits the glucagon receptor simultaneously. Glucagon activation directly signals fat cells to release and oxidize stored lipids — effectively adding a turbo mechanism to energy expenditure research that single or dual agonists simply cannot replicate.

✓ Lipolysis Activation · Unique Triple Synergy
04 · EXTENDED HALF-LIFE
Once-Weekly Activity Window

Engineered with an attached fatty acid chain, GLP-3R demonstrates prolonged stability in research settings — remaining active for up to 6 days. This extended duration reduces dosing frequency while maintaining consistent receptor engagement, making it highly efficient for long-cycle metabolic studies.

✓ ~6-Day Activity · Once-Weekly Protocol
GLP-3R Features

Everything You Get
With GLP-3R

Eight research advantages in a single vial · Unmatched in the peptide landscape

📦
FORMAT
Lyophilized Freeze-Dried Powder

Supplied in a sealed vial as lyophilized powder — the gold-standard format for research peptides. Stays stable longer, ships safely, and provides a clean, consistent starting point every time you reconstitute it.

⚡
SYNERGY
Appetite Suppression + Energy Burn Together

Most peptides reduce hunger OR burn fat — not both. GLP-3R does both simultaneously. The GLP-1 receptor cuts appetite; the glucagon receptor tells fat cells to burn energy. Study both mechanisms in one clean protocol.

🧬
SYNERGY
Synergistic Multi-Pathway Effects

Hitting all three receptors at once creates a compounding effect — the combined result is stronger than each pathway individually. Preclinical models confirm GLP-3R outperforms separate compounds given together. One peptide, amplified results.

🔬
01
Improved Insulin Sensitivity Research

Activates both GLP-1 and GIP incretin pathways, boosting cellular insulin response. Research data shows meaningful improvements in blood sugar regulation — ideal for diabetes and metabolic disorder research.

GLP-1GIPInsulin
❤️
02
Lowers Triglycerides & Bad Cholesterol

Published research shows GLP-3R reduces ANGPTL3/8 — the protein responsible for raising triglycerides and LDL cholesterol — via the glucagon receptor pathway. A powerful tool for cardiovascular and lipid metabolism researchers.

LDLTriglyceridesCardiovascular
🧠
03
Central Nervous System Appetite Signaling

GLP-1 receptor activation reaches the hypothalamus directly, affecting hunger regulation at the brain level — not just in the stomach. GLP-3R opens CNS-metabolic crossover research that single-target peptides simply cannot access.

HypothalamusCNSAppetite
🦴
04
Obesity & Type 2 Diabetes Research

Validated research models for both obesity and T2D make GLP-3R one of the most versatile metabolic compounds available. Covers two of the largest disease research verticals simultaneously.

ObesityT2DMetabolic
💪
05
Preserves Lean Muscle While Reducing Fat

Phase 2 trial data confirms that the majority of body weight reduction with GLP-3R comes from fat mass — not lean muscle. This makes it uniquely valuable for body composition research protocols.

Lean MuscleBody CompFat Loss
LYOPHILIZED
Product Format

Supplied as Lyophilized
Freeze-Dried Powder

Every vial of GLP-3R is manufactured as lyophilized powder — water carefully removed under vacuum to leave a stable, full-potency peptide. Reconstitute with sterile bacteriostatic water when ready to use. Store dry at −20°C long-term. Use within 28–30 days after reconstitution. No guesswork, no degradation in transit.

−20°C
Long-term storage
28–30d
After reconstitution
~99%
Purity guaranteed
Body Weight Change in Phase 2 Study (48 Weeks)*
GLP-3R 12mg −24% body weight
−24%
Tirzepatide (dual) −22% body weight
−22%
Semaglutide (single) −15% body weight
−15%
48wkTrial Duration
338Participants
NEJMPublished In
2023Phase 2 Results
NEJM · 2023 PubMed Indexed NCT04881760
The Science

Real Study Data You
Can Trust

GLP-3R isn't a new compound without evidence. It's been studied in one of the largest clinical trials ever conducted for metabolic research — published in the New England Journal of Medicine.

01 · PHASE 2 TRIAL RESULT
The Biggest Weight Loss Ever Seen in a Drug Study

The Phase 2 trial showed up to 24% body weight reduction at 48 weeks — the largest number ever recorded at that point in any drug study. The curve was still going down at study end. The plateau had not been reached.

02 · BODY COMPOSITION
Almost All the Weight Lost Was Fat, Not Muscle

Research confirms that the vast majority of weight reduction with GLP-3R came from fat mass — not lean tissue. This makes it far more valuable for body composition research than simple calorie restriction models.

03 · SYNERGY CONFIRMED
Outperforms Three Separate Compounds Combined

Researchers who tested separate compounds for each receptor found the individual results did not stack additively. The fact that one molecule hits all three simultaneously creates a molecular synergy that cannot be replicated by mixing compounds.

30 DAY
MONEY
BACK
Our Promise To You

We Stand Behind Every
Single Vial We Ship

We've built PureOne Peptides on trust, and we plan to keep it that way. If you're not completely satisfied with your order for any reason — purity, consistency, delivery, anything — just reach out within 30 days and we'll make it right. No hoops, no questions designed to discourage you. Just a full refund or replacement, your choice.

✓Full refund or replacement
✓No complicated return process
✓30 days from delivery date
✓Any reason, zero questions
✓Response within 1 business hour
Social Proof

What Researchers
Are Saying

Verified purchases · Independent researchers · Real outcomes

4.9 Average Rating
2,400+ Verified Reviews
98% Would Reorder
50K+ Active Researchers
★★★★★

"We've been using PureOne's GLP-3R in our obesity research for months now. The purity is excellent every single time — our HPLC always confirms 99%+."

MK
M. Katsaris
Boston, MA
Verified Purchase
★★★★★

"Ordered on a Tuesday morning and it was at our lab by end of day. The lyophilized powder format is exactly what we need — it's stable, easy to reconstitute, and the concentration is spot on every time. PureOne is our go-to now."

TR
T. Ramos, M.Sc.
San Diego, CA
Institutional Client
★★★★★

"I was skeptical at first but the consistency between batches has been impressive. Six months of ordering and every CoA shows clean results. Our liver research has moved so much faster thanks to having a reliable triple-agonist compound."

SL
S. Lindqvist
Chicago, IL
Verified Purchase
FAQ

Got
Questions?

We've compiled answers to the most common questions from our research community. Can't find what you need? Our scientific advisory team responds within one business hour.

How does it ship and how do I store it? +
Our GLP-3R is supplied as a lyophilized (freeze-dried) powder in sealed vials — this format keeps the peptide stable and protected during shipping and storage. When it arrives, store the dry powder in a cool, dry, dark place. For longer storage, keep it at -20°C. Once you reconstitute it with bacteriostatic water or appropriate buffer, keep it in the fridge at 2–8°C and use it within 28–30 days. Avoid repeated freeze-thaw cycles to preserve compound integrity.
How is it different from GLP-1S compounds? +
GLP-1S only activates one receptor (GLP-1). That's good, but it's like a one-trick pony. GLP-3R activates three receptors at once — GLP-1, GIP, and glucagon. The glucagon part is what really sets it apart, because it directly tells fat cells to burn up, which GLP-1S can't do at all.
What's in the Certificate of Analysis? +
The CoA is a document that proves the quality of what you're getting. It includes: the exact purity percentage from HPLC testing, mass spectrometry confirmation of the right molecule, batch number, date it was made, how to store it, and the molecular weight and formula. You can use it in your research documentation.
How pure is it? How do you check? +
Every batch is made to ≥99% chemical purity. We verify this using HPLC (a machine that separates and measures each chemical) and Mass Spectrometry (which confirms the exact molecule). A Certificate of Analysis comes with every order so you can see the numbers yourself. We also encourage you to run your own test.
Why is it supplied as a lyophilized powder? +
Lyophilized (freeze-dried) powder is the gold standard format for research peptides. Removing the water from the compound during manufacturing makes it much more stable — it can be stored at room temperature short-term or at -20°C long-term without degrading. This format also makes shipping easier and safer. When you're ready to use it in your research, simply reconstitute with sterile bacteriostatic water or an appropriate buffer solution. The result is a consistent, clean, measurable concentration every time — which is critical for reproducible research results.
What if I'm not happy with my order? +
Easy — just contact us within 30 days. If the product doesn't match the CoA, fails your own purity test, or arrives damaged, we'll send a replacement or give you a full refund. No questions asked. We want every researcher to be completely confident ordering from us.
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